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Hypertension: The recommended starting dose of Carvedilol is 6.25 mg twice. If this dose is tolerated, the dose should be maintained for 7 to 14 days, and then increased to 12.5 mg twice daily. The dose may be increased further, if necessary, at intervals of at least two weeks, to 50 mg once daily or in divided doses, or as prescribed by the physician. A dose of 12.5 mg once daily may be adequate for elderly patients.
Heart Failure: The initial dose is 3.125 mg twice daily by mouth. If tolerated, the dose should be doubled after two weeks to 6.25 mg twice daily and then increased gradually, at intervals not less than two weeks, to the maximum dose tolerated, this should not exceed 25 mg twice daily in patients with severe heart failure or in those weighing less than 85 kg (187 lbs) or 50 mg twice daily in patients with mild to moderate heart failure weighing more than 85 kg, or as prescribed by the physician. It should be taken with food to reduce the risk of hypotension.
Angina Pectoris: Initial dose of 12.5 mg twice daily by mouth, increased after two days to 25 mg twice daily or as prescribed by the physician.
Left Ventricular Dysfunction following Myocardial Infarction: The initial dose is 6.25 mg twice daily, increased after 3 to 10 days, if tolerated, to 12.5 mg twice daily and then to a target dose of 25 mg twice daily. A lower initial dose may be used in symptomatic patients. Or as prescribed by the physician.
